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Fig. 3C. —61-year-old woman with metastatic linitis plastica of rectum. Patient underwent total gastrectomy for gastric cancer (poorly differentiated type) 45 months previously and then underwent palliative sigmoid loop colostomy for rectal obstruction. Photomicrograph shows diffuse involvement of entire wall by poorly differentiated adenocarcinoma. Mucosa is eroded (arrowheads) and submucosa (SM) and subserosa (SS) are significantly thickened because of tumor infiltration and reactive fibrosis. Compared with healthy corresponding layer (arrows), proper muscularis (PM) is considerably thickened because of hypertrophic changes of muscle fiber and tumor infiltration. (H and E, x5)