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Fig. 6. —58-year-old man with negative digital rectal examination and rising prostate-specific antigen levels in last 3 years who had undergone three sets of transrectal sonographically guided biopsies (including transitional zones) with negative results. His recent prostate-specific antigen level was 18 ng/mL. Helical CT scan of prostate shows small area of abnormal contrast enhancement in posterior portion of right peripheral zone (arrow), suggestive of cancer. Repeated transrectal sonographically guided biopsy with particular emphasis to this area (six core biopsy samples) allows detection of adenocarcinoma in 50% of only one core biopsy sample and Gleason score of 6. No other focus of tumor was found (total of 14 core biopsy samples).