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Fig. 4B. —Prevention of cardiac hypertrophy in transgenic mice by calcineurin inhibition. Heart specimens were taken from genetically identical mice (tropomodulin-overexpressing transgenic). Images were digitized with slide scanner and then enlarged using software (Photoshop; Adobe Systems, Mountain View, CA). rv = right ventricle, lv = left ventricle. (Reprinted with permission from [20]) Histologic specimen from mouse treated with cyclosporin reveals normal heart. (H and E)