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Fig. 1. —Drawing shows principle of phase-inversion sonography. Two pulses that are 180° out of phase are sent immediately back-to-back, and returned signals are summed to form one sonographic frame. In case of exclusively linear scattering without distortion, this summation produces a signal void. Nonlinear response from microbubbles, including harmonic resonance and stimulated acoustic emission (SAE), distorts returned signals, and thus summation of two pulses no longer results in signal void. Resulting signal is particularly strong in presence of bubble destruction and SAE because destroyed bubble can no longer produce a response to second pulse, so that strong signal from first pulse is used without any subtraction from second pulse.