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Fig. 3C. —50-year-old woman, a nonsmoker, with well-differentiated adenocarcinoma (16 x 18 mm) (type C of Noguchi et al. [11]) in apical segment of upper lobe of right lung. Photomicrograph of histology specimen shows dense fibrotic tissue, thickened alveolar septa, and collapsed alveoli in central zone (C), as well as tumor cell growth in alveolar lining and deformed alveoli in peripheral zone (P), which corresponds to type C. (H and E, x1.25)