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Fig. 5. —Graph shows mean relative enhancement time course curve in healthy volunteers ({blacksquare}), in lung cancer patients without pulmonary emphysema ({diamondsuit}), and in lung cancer patients with pulmonary emphysema ([UNK]). Maximum mean relative enhancement ratios in lung cancer patients (without emphysema, 18.4 ± 1.3 %SI [percentage increase of signal intensity]; with emphysema, 15.5 ± 3.3 %SI) are significantly less than those of healthy volunteers (31.8 ± 2.7 %SI) (p < 0.001). Mean slopes of relative enhancement of lung cancer patients (without emphysema, 0.50 ± 0.02 %SI/sec; with emphysema, 0.05 ± 0.02 %SI/sec) are significantly less than those of healthy volunteers (0.69 ± 0.06 %SI/sec) (p < 0.001). Mean slope of relative enhancement of lung cancer patients with pulmonary emphysema is significantly less than that of lung cancer patients without emphysema (p < 0.001).