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Fig. 4B. —Illustrations show effect of interstitial pressure in tumor on transport of contrast agents and drugs across vessel wall into tumor interstitium. High pressure in tumor interstitium minimizes convective (pressure gradient—driven) transfer of molecules out of vessels and to targeted tumor cells. Convective transfer is particularly important for large molecules, which move slowly by diffusion. Interstitial pressure is elevated almost uniformly throughout most of tumor. Pressure drops off at tumor periphery, resulting in a pressure gradient that drives molecules out of tumor by convection.