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Fig. 4E. Percutaneous ethanol injection guided by CO2-enhanced sonography in 67-year-old man with Child's class B cirrhosis [9] and large hepatocellular carcinoma (maximum diameter, 100 mm) in residual tumor after initial treatment. Conventional abdominal radiograph shows tips of needles corresponding to tumor staining shown on digital subtraction angiogram (arrowhead and arrows). Additional percutaneous ethanol injection therapy was performed seven times after original injection guided by CO2-enhanced sonography.