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Fig. 5B. —34-year-old man with new onset of generalized seizures. Permeability maps show that areas of high permeability can be seen in regions that do not densely enhance on T1-weighted images. Permeability map shows multiple cortical and subcortical areas of elevated permeability in tumor region seen in A. Mean regional permeability value in tumor measured 0.041, and single area of maximum permeability value measured 0.045. Surgical biopsy showed World Health Organization grade II well-differentiated astrocytoma, but pathology report noted that MIB-1 labeling index (a measure of mitotic activity) measured 5-10%, which is much more indicative of aggressive high-grade neoplasm than of typical low-grade neoplasm.