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Fig. 4B. —46-year-old woman with 3-month history of nipple retraction and vague palpable mass at 12-o'clock position who underwent MR imaging for assessment of disease extent. Sagittal enhanced three-dimensional T1-weighted fast spoiled gradient-recalled MR image (TR/TE, 17/2.4; flip angle, 35°) depicts at least seven separate irregular and spiculated masses (arrows) with heterogeneous enhancement in regional distribution, highly suggestive of malignancy. This area was bracketed with MR imaging guidance using three wires (not shown). Pathology at surgical biopsy revealed multiple sites of infiltrating mixed ductal and lobular carcinoma as well as ductal carcinoma in situ, with positive margins. Patient ultimately underwent mastectomy.