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Fig. 1B. —Drawings illustrate migration of neural crest cells and development of branchial arches. Branchial arches develop in craniocaudal sequence. First branchial arch (I) begins to form at approximately day 22 of gestation; second (II) and third (III) arches, at day 24 of gestation; and fourth (IV) and sixth (VI) arches, at day 29 of gestation.