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Fig. 4. —Box-and-whisker plot of mean transit time in regions with severely decreased (percentage of cerebral blood flow increase, 0%), moderately decreased (percentage of cerebral blood flow increase, > 0% but15%), and normal (percentage of cerebral blood flow increase, >15%) perfusion reserve. Note that regions with severely decreased perfusion reserve show significantly higher mean transit time values than those with moderately decreased or normal perfusion reserves (p = 0.0004 and p < 0.0001, respectively). Boxes represent 25-75% range, with bisecting lines showing median values; horizontal lines represent 10-90% range. NS = not significant.