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Fig. 2A. —53-year-old man with aggressive systemic mastocytosis with splenomegaly, ascites, and biopsy-proven mast cell infiltration of liver, skin, and skeleton. Sagittal gradient-echo T1-weighted MR image (TR/TE, 180/4) of lumbar spine shows hypointense bone marrow compared with intervertebral disks, suggesting deposition of mast cells and partial replacement of fatty marrow.