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Fig. 1. —Receiver operating characteristic curve. Graph shows differentiation of malignant from benign lesions using contrast-enhanced sonography in late phase of contrast enhancement. We set cutoff value at 3. Broken line represents baseline sonography; solid line represents contrast-enhanced sonography. Sensitivity and specificity of contrast-enhanced sonography for differentiation between benign and malignant lesions were significantly higher than those of B-mode sonography.