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Fig. 1A. —Illustration of how time points are selected for three-time-point method. Modeling parameter K refers to the vascular permeability x surface area product per unit volume. Modeling parameter EVF refers to extracellular volume fraction. Graph shows hypothetic signal intensity (SI) enhancement versus time profiles for malignant (red curve) and benign (blue curve) lesions after gadopentetate dimeglumine injection. In this simulation, values used for malignant lesion were K = 0.95 min^-1, EVF = 0.5; and for benign lesion, K = 0.3 min^-1, EVF = 0.5. Curves were generated using model-based equation that accounted for MR imaging sequence parameters and T1 relaxation rate, as well as dose, relaxivity, and blood pharmacokinetics of contrast agent. Vertical dotted lines simulate SI measurements taken at selected time points. Note rules by which three-time-point method codes spatial coordinate as red, green, or blue on basis of SI differences between second and third time points: red, SI decrease; green, SI stable; blue, SI increase.