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Fig. 5C. —60-year-old woman with low- to intermediate-grade ductal cancer in situ (false-negative study). Optical close-up of sagittal three-time-point MR image shows area of predominantly bright green pixels thought to be benign (score, 2). Three of eight ductal carcinoma in situ (DCIS) lesions were misdiagnosed as benign by three-time-point method. Area of future investigation is to determine whether a specific pattern for DCIS will allow increased accuracy of diagnosis.