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Fig. 1B. —Illustration of how time points are selected for three-time-point method. Modeling parameter K refers to the vascular permeability x surface area product per unit volume. Modeling parameter EVF refers to extracellular volume fraction. Calibration map results show SI measurements at 0, 0.5, and 6 min. Simulated benign and malignant lesion values of K and EVF referred to in A are shown as points B and M, respectively. Three-time-point calibration map shows assignment of overlay color based on SI measurement changes. Choice of inappropriately early second time point (0.5 min) leads to both benign and malignant simulated lesions being coded blue, or benign, because SI of malignant lesion has not yet peaked (0.5 min < its SI at 6 min). Superimposed yellow curves are isoslopes of wash-in values—the faster the wash-in, the brighter the overlay color.