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Fig. 1C. —Illustration of how time points are selected for three-time-point method. Modeling parameter K refers to the vascular permeability x surface area product per unit volume. Modeling parameter EVF refers to extracellular volume fraction. Calibration map results show SI measurement at 0, 2, and 12 min. Choice of inappropriately late third time point (12 min) leads to benign lesion being coded as indeterminate—in green rather than in blue zone (confident benign). Malignant lesion is appropriately coded as red.