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Fig. 1D. —Illustration of how time points are selected for three-time-point method. Modeling parameter K refers to the vascular permeability x surface area product per unit volume. Modeling parameter EVF refers to extracellular volume fraction. Calibration map results show SI measurements at 0, 2, and 6 min. Optimal choice of both second and third time points (2 and 6 min, respectively) produces desired result—correct discrimination and color coding of malignant lesion as red and benign lesion as blue. Note correct choice of time points typically equally divides K-EVF plane into symmetric zones of equal red and blue. Width of green (indeterminate) area is governed by definition of lack of defined change in slope between second and third time points (in our case, ± 10%). Once this calibration map was set for MR imaging parameters used in our study, data for all clinical patients were taken at same time points and used same rules to reach diagnosis.