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Fig. 2B. —69-year-old woman with island of benign breast tissue simulating mass (true-negative study). Three-time-point sagittal parametric MR image shows virtually all dark blue pixels (more apparent on computer screen), indicating lesion with low values of K (vascular permeability x surface area product per unit volume) and EVF (extracellular volume fraction), which are indicators of benignity. Prospective three-time-point diagnosis was benign (suspicion level 2).