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Fig. 2C. —63-year-old woman with colon carcinoma. Pulse inversion harmonic digital sonograms are serial scans obtained respectively at 20 (B), 100 (C), and 180 (D) sec after Levovist ([SH U 508A] Schering, Berlin, Germany) injection. One liver lesion (arrow) is visible in all scans, but is better seen in C and D, and appears hypoechoic in comparison with surrounding normal liver parenchyma, which is hyperechoic because of Levovist administration. Lesion was confirmed on MR imaging (not shown) and proven to be metastasis after resection.