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Fig. 9A. —Results of CT measurements and calculations with three-compartment
model for contrast medium concentrations in vascular space and interstitium in
74-year-old patient with good renal function treated with right-sided
percutaneous nephrostomy for ureteral stone. Volume of both kidneys was 578
mL. Glomerular filtration rate (GFR) measured by plasma clearance was 113
mL/min. CT GFR was 129 mL/min. Lower curve (A and B) represents
contrast medium concentration in interstitial space. Parameters are more fully
defined in Appendix 1. Graph shows contrast medium concentrations in vascular
space as measured with CT, b(t) (
). As long as contrast medium
concentration in interstitial space, I(t) (
), is lower than
that in vascular space, contrast medium flows into interstitial space.
Equilibrium is reached approximately 110 sec after contrast injection. 
= b(t) interpolated.