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Fig. 10B. —Contrast medium concentrations as results of three-compartment model calculations and CT measurements in patient with markedly swollen kidneys (shown in Figs. 8A, 8B) caused by bilateral pyelonephritis with hydronephrosis and treated with percutaneous nephrostomy on left side. Patient had low glomerular filtration rate (GFR). Interstitial space was calculated to be 46%. Parameters are more fully defined in Appendix 1. Graph shows contrast medium amount in vascular space, B(t) ({blacksquare}); in interstitial space, I(t) ({blacktriangleup}); and excreted into nephron as result of model calculations and CT measurements. Amount of contrast medium in interstitial space is much greater than amount excreted into nephron. Most contrast medium measured with CT (KCT) represents contrast medium in interstitial space. Calculated Patlak plot [3] is curved line with slope that is initially steep and later flattens. • = amount of contrast medium in nephron, N(t); {blacktriangledown} = amount of contrast medium in kidney, K(t); {diamondsuit} = contrast medium measured with CT (KCT).