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Fig. 2. Three-compartment model shows contrast medium distribution in
kidney. Contrast medium is injected into vascular space. Bidirectional flow
into and out of interstitial space is proportional to difference in contrast
medium concentration between two compartments. Unidirectional contrast medium
flow from vascular space into nephron is proportional to plasma concentration
(i.e., clearance definition). Parameter definitions are given in Appendix
1.