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Fig. 4C. —70-year-old woman with multiple metastatic vertebrae from lung cancer who died 12 days after MRI examination. Autopsy revealed necrosis in central regions and viable tumor cells in peripheral regions. Contrast-enhanced T1-weighted spin-echo image (550/8) shows heterogeneity of metastatic vertebrae. Regions of faint or no enhancement correspond to high signal areas on T2-weighted images, suggesting necrosis.