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Fig. 6B. —49-year-old man with pathologically confirmed grade IV acute gastrointestinal graft-versus-host disease. Photomicrographs of histopathologic rectosigmoid biopsy specimens reveal findings that confirm diagnosis. Low-power image (A) shows surface ulceration (arrow, A, indicating surface), with absence of glands in mucosa, crypt cell dropout, and nearly complete loss of epithelium, whereas high-power image (B) reveals epithelial cell apoptosis (arrow, B) and lymphocytic infiltration of lamina propria. (H and E, both slides)