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Fig. 2A. —Progression of trilateral retinoblastoma in girl (patient 6) who was diagnosed with bilateral ocular retinoblastoma when 1 month old. Intracranial tumor was discovered when patient was 8 months old and remained stable for 26 months. Patient died at age of 3 years. Unenhanced axial CT scan obtained when girl was 8 months old shows calcified pineal mass that did not enhance after administration of contrast material. Hyperdense region in left frontal lobe presumably reflects radiation changes secondary to radiation therapy for retinoblastoma in left eye. Finding remained stable on multiple subsequent imaging studies.