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Fig. 3A. —13-year-old boy (patient 7) who was 2 months old when bilateral retinoblastoma and pineal neoplasm were diagnosed, He was treated with radiation therapy and chemotherapy. Size of intracranial mass markedly decreased after many months of treatment, No evidence of central nervous system metastases was found. However, 10 years after apparently successful therapy, metastasis in right ulna was discovered. Contrast-enhanced axial CT scan obtained through the orbits when patient was 2 months old shows bilateral calcified ocular masses, consistent with retinoblastoma.