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Fig. 3C. —13-year-old boy (patient 7) who was 2 months old when bilateral retinoblastoma and pineal neoplasm were diagnosed, He was treated with radiation therapy and chemotherapy. Size of intracranial mass markedly decreased after many months of treatment, No evidence of central nervous system metastases was found. However, 10 years after apparently successful therapy, metastasis in right ulna was discovered. Contrast-enhanced axial MR image of brain obtained 8 weeks after B (6 weeks after beginning chemotherapy) shows that size of nonenhancing pineal tumor has somewhat decreased compared with its size in B. After radiation therapy and chemotherapy, size of mass further decreased over next few months. No metastases of central nervous system have developed during follow-up period of more than 13 years.