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Fig. 3D. —13-year-old boy (patient 7) who was 2 months old when bilateral retinoblastoma and pineal neoplasm were diagnosed, He was treated with radiation therapy and chemotherapy. Size of intracranial mass markedly decreased after many months of treatment, No evidence of central nervous system metastases was found. However, 10 years after apparently successful therapy, metastasis in right ulna was discovered. Contrast-enhanced axial T1-weighted image obtained 10 years after C shows enhancing soft-tissue mass (arrows) surrounding right ulna that represents periosteal reaction and tumoral infiltration. Biopsy of mass revealed small cell malignant neoplasm that is histopathologically consistent with metastatic retinoblastoma or new undifferentiated malignant tumor.