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Fig. 6C. 44-year-old woman with large unifocal breast tumor. MR image obtained after chemotherapy shows only two or three low-enhancing residual foci (arrows). Patient underwent secondary mastectomy after breast-conserving surgery resulted in positive margins. Size of residual tumor at histology (3.5-cm invasive lobular carcinoma) was underestimated by 1.5 cm. MRI evaluation would not have prevented additional breast-conserving surgery in this patient.