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Fig. 4B. —Illustration of final Cox model using Kaplan-Meier curves for length of recurrence-free survival (RFS). Resulting model from stepwise Cox analysis showed initial MRI tumor volume (p = 0.0051) and final change in MRI tumor volume (p = 0.0028) to be most significant independent predictors. Vol = volume decrease. Patients divided based on amount of volumetric tumor shrinkage experienced during treatment also showed significant differences in RFS (p = 0.012, Wilcoxon's test). The 2-year RFS rate was 87% for patients with 50% or greater reduction in tumor volume (n = 47) compared with 64% for those with less than 50% tumor shrinkage (n = 11) during treatment.