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Fig. 2C —59-year-old woman with recently diagnosed contralateral (left) breast invasive lobular cancer, who had suspicious right breast mass on MRI examination to assess for other sites of cancer in ipsilateral and contralateral breasts. Sagittal T1-weighted contrast-enhanced images show how radiologist determines skin-entry site and depth of insertion of needle. Image on left is same contrast-enhanced sagittal T1-weighted scout image showing the lesion in B, with cursor (x) placed over lesion. Image on far right shows vitamin E marker, with different cursor (o) placed over it. Image in center is skin surface, which is identified by indentations from grid lines, evident as low signal-intensity lines like a tic-tac-toe board. By correlating location of cursors over lesion and vitamin E marker on middle image, skin-entry site of needle (i.e., appropriate square and location within square of grid) is determined. Depth of needle insertion is equal to distance between skin (sagittal slice with low signal intensity lines) and lesion; this is determined by multiplying number of sagittal slices between skin and lesion by slice thickness (3 mm).