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Fig. 1D —56-year-old woman presenting with a typical region of MALT lymphoma on MRI. Sagittal T2-weighted fast spin-echo fat-suppressed MR image of right breast; (TR/TE 4,000/98, slice thickness 3 mm, slice spacing 3 mm; field of view 20 cm, acquisition matrix 256 x 192) shows ovoid 1.6 x 0.7 cm lesion (arrow) in upper breast, with slightly higher signal intensity than adjacent glandular tissue (A). Contrast-enhanced water-specific 3D gradient-echo image (centric 3D spectral-spatial excitation spoiled gradient echo with magnetization transfer [3DSSMT] after 0.1 mmol/kg IV of gadopentetate dimeglumine, TR/TE 31.3/8.73, slice thickness 1.5 mm, field of view 20 cm, matrix 512 x 192) revealed multiple foci of contrast enhancement, largest being 1.6 x 0.7 cm in upper outer quadrant (arrow) (B) that had increased in size and number since previous study 5 months earlier (not shown). Time signal-intensity curves from dynamic 3D spiral MRI (scans repeated every 10.6 sec; see reference [6] for scan parameter details) performed during initial contrast enhancement ("wash-in" phase) and after high-resolution 3DSSMT ("wash-out" phase) revealed rapid initial enhancement during wash-in phase followed by gradual enhancement during wash-out phase (C). MRI localized biopsy of upper breast lesion revealed dense lymphoid infiltrate composed of monomorphous small lymphocytes involving breast parenchyma and surrounding benign breast ducts (D) (H and E stain x100). Histologic findings were same as MRI-guided biopsy of initial left breast lesion (not shown).