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Fig. 2A —Use of T1-weighted dynamic contrast-enhanced technique to evaluate permeability in patient with residual high-grade glioma after previous resection. Technique uses dynamic contrast-enhanced 3D spoiled gradient imaging sequence obtained every 6.45 sec for 58 sec after IV infusion of 0.1 mmol/kg of gadopentetate dimeglumine. Before contrast material infusion, five unenhanced T1-weighted spoiled gradient images are obtained, each using different flip angle to derive T1 values of tissue needed for analysis of permeability. Anatomic image obtained using contrast-enhanced T1-weighted spoiled gradient sequence through tumor shows lesion to have inhomogeneous contrast enhancement, with periphery of tumor having more marked contrast enhancement than central portion.