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Fig. 2C —Use of T1-weighted dynamic contrast-enhanced technique to evaluate permeability in patient with residual high-grade glioma after previous resection. Technique uses dynamic contrast-enhanced 3D spoiled gradient imaging sequence obtained every 6.45 sec for 58 sec after IV infusion of 0.1 mmol/kg of gadopentetate dimeglumine. Before contrast material infusion, five unenhanced T1-weighted spoiled gradient images are obtained, each using different flip angle to derive T1 values of tissue needed for analysis of permeability. Color-coded quantitative map of degree of contrast enhancement, an indirect measure of permeability, superimposed on image in A depicts pixels that have peak signal intensity values between 120% and 139% of mode signal intensity value of contralateral hemisphere in blue, those between 140% and 159% in yellow, and those greater than 160% in red. Most of tumor has marked degree of contrast enhancement due to disruption of blood-brain barrier, and central portion has lower degree of enhancement, reflecting relatively well appearance of K_trans map in B.