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Fig. 1 —Comparison of tumor enhancement with ultrasmall superparamagnetic iron oxides (USPIO) versus gadolinium (Gd) chelate in 67-year-old woman with recurrent gliosarcoma (World Health Organization grade IV). Lesion in right frontoparietal lobe shows homogeneous, circular enhancement of gadolinium. On T1-weighted sequences (top row), enhancement of USPIO is less distinct. Gadolinium-enhancing area of radiation necrosis (arrowhead) along course of catheter for interstitial radiation therapy (black arrows on unenhanced images) does not enhance with USPIO (arrowhead). Posteromedially to lesion, area of neovascularization (white arrow) is depicted. On T2^*-weighted images (bottom row), corresponding area enhances strongly with USPIO (white arrow).