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Fig. 5 —Bar-and-whisker chart shows change of normalized signal intensity in enhancing tumor rind and in enhancing solid tumor parts on T1-weighted images with gadolinium (Gd), T1-weighted images with ultrasmall superparamagnetic iron oxides (USPIO), and T2^*-weighted images with USPIO. On T1-weighted Gd series, normalized changes of signal intensity were most prominent, with a mean decrease in enhancing tumor rind (dark gray bars) of 52.3% ± 23.4% (SD) and in enhancing solid tumor parts (light gray bars) of 53.7% ± 22.1%. On T1-weighted USPIO series, changes of normalized signal intensity were slightly less distinct measured in corresponding enhancing parts of tumor. Changes measured in tumor rind were 40.1% ± 26.7% and in solid tumor parts were 47.2% ± 31.9%. Decrease of signal intensity in enhancing areas of tumor was less pronounced on T2^*-weighted USPIO images; it measured 33.1% ± 18.4% in enhancing tumor rind and 28.4% ± 16.4% in enhancing solid tumor parts. Changes of signal intensity on T1- and T2^*-weighted USPIO images were statistically significant in relation to T1-weighted Gd images (p < 0.015). Error bars indicate confidence interval.