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Fig. 1 Sagittal dynamic contrast-enhanced MR images of albumin-injected
knee showing unenhanced (A, F, K) and contrast-enhanced (B-D, G-I,
L-N) images obtained on days 0 (before induction, A-D), 1 (after
induction, F-I), and 28 (after induction, K-N) of arthritis. G,
(day 1 of arthritis), Evidence of synovial inflammation with joint effusion
and synovial enhancement (arrows) noted in suprapatellar (long
arrow) and posterior recess (short arrow) of knee. Although
level of synovial inflammation decreased in interval between days 1 and 28 of
arthritis, persistent synovial reaction is identified (arrowheads,
L) in chronic stage of arthritis. D, I, and N,
Regions-of-interest used to delineate the perisynovial region to derive
time-intensity curves for that joint on days 0 (E), 1 (J) and 28
(O) of arthritis. Note the increased signal slope seen in the acute
stage of arthritis (day 1, J) as compared with the slopes obtained on
days 0 (E) and 28 (O) of arthritis.