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Figure 1


Fig. 1 —Sagittal dynamic contrast-enhanced MR images of albumin-injected knee showing unenhanced (A, F, K) and contrast-enhanced (B-D, G-I, L-N) images obtained on days 0 (before induction, A-D), 1 (after induction, F-I), and 28 (after induction, K-N) of arthritis. G, (day 1 of arthritis), Evidence of synovial inflammation with joint effusion and synovial enhancement (arrows) noted in suprapatellar (long arrow) and posterior recess (short arrow) of knee. Although level of synovial inflammation decreased in interval between days 1 and 28 of arthritis, persistent synovial reaction is identified (arrowheads, L) in chronic stage of arthritis. D, I, and N, Regions-of-interest used to delineate the perisynovial region to derive time-intensity curves for that joint on days 0 (E), 1 (J) and 28 (O) of arthritis. Note the increased signal slope seen in the acute stage of arthritis (day 1, J) as compared with the slopes obtained on days 0 (E) and 28 (O) of arthritis.