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Fig. 3B —Areas under the curve of individual MRI parameters used for discrimination of inflammatory status of joint on days 1 (A) and 14 (B) of arthritis. Line graphs show differences in areas under the curve for five different MRI parameters in early arthritis (difference of areas under the curve between time-to-peak (TTP) and other parameters on day 1, p = 0.0002 (A) and between signal slope (dS/dt), capillary permeability (K^PS and other parameters on day 14, p = 0.001, B). The areas under the curve of time-to-peak, maximal signal change (S), signal slope, capillary permeability and leakage space volume (V_E) were 0.875, 0.727, 0.656, 0.625, 0.586 on day 1 (A) and 0.667, 0.694, 0.944, 0.944 and 0.889 on day 14 (B), respectively. Dashed line = time-to-peak, crossed line = signal slope, thick solid line = capillary permeability, dotted line = maximal signal change, thin solid line = leakage space volume.