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Fig. 1B Criteria for visual diagnosis of solid liver tumors after
microbubble contrast agent injection. Higher, similar, or lower in
echogenicity compared with adjacent liver was assessed, respectively, as
hypervascular (subjective conspicuity = 1 or 2), isovascular (subjective
conspicuity = 0), or hypovascular (subjective conspicuity = -2 or -1).
Criteria used for visual diagnosis of benignancy: Diffuse indicates that
enhancement of whole lesion was homogeneous or heterogeneous; peripheral
nodular, discontinuous or continuous peripheral enhancement with nodular
appearance; central spoke-wheel-shaped, enhancing central vessel appeared to
branch toward the periphery of the lesion; and absent, no difference before
and after microbubble injection, with persistent hypovascular appearance.