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Fig. 5 —Temporal change of median tumor volume between ROI-based and diameter-based methods. Sequential median tumor volume before, during, and after radiation therapy (RT) shows that tumors appear larger when measured with diameter-based method (solid line) compared with 3D ROI method (dashed line). This is likely related to overestimation of tumor volume with diameter-based method because maximal orthogonal diameters used for ellipsoid computation cannot adequately account for deviation of tumor shape from presumed oval or ellipsoid tumor shape.