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Fig. 2A —16-year-old boy with chronic granulomatous disease (CGD) shows typical histologic appearance of hepatic abscess. Unlike most abscesses, center of abscess in CGD is filled with neutrophils and cell debris, and this core is surrounded by palisade epithelioid histiocytes and then by layer of histiocytes mixed with other inflammatory cells (mainly lymphocytes). Around this is wide zone of fibrous and inflamed granulation tissue. Typical abscesses showed liquified necrosis centrally. (H and E, x40)