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Fig. 7 —67-year-old woman with enlarging 8 x 7 mm left lower lobe pulmonary nodule first detected on low-dose screening chest CT. Axial ¹⁸F-FDG PET image shows focus of increased metabolic activity in posterior left lung base (arrowhead) correlating with location of nodule. During blinded, qualitative review, two experienced nuclear radiologists independently interpreted this nodule as malignant; however, measured standardized uptake value maximum was 1.7, below 2.5 threshold for malignancy and favoring benign cause. Histology of resected nodule revealed grade 2 adenocarcinoma.