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Fig. 1A —62-year-old man with glioblastoma multiforme. Depiction of
changes in leakage of contrast material (a reflection of degree of
permeability across blood-brain barrier) after administration of
antiangiogenic agent directed against vascular endothelial growth factor
(VEGF) receptor tyrosine kinase. Series of images shows additional physiologic
information provided by dynamic imaging relative to solely anatomic
information provided by conventional MRI. Because imaging findings solely
reflect effect of angiogenesis (i.e., permeability), this technique is an
example of indirect imaging of angiogenesis. Contrast-enhanced axial
T1-weighted image obtained before therapy shows large enhancing mass located
in left temporal lobe.