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Fig. 4C —Use of ß₃ integrin-targeted microbubbles to directly depict angiogenesis in intracerebral gliomas in rats. (Reprinted with permission from Ellegala DB, Leong-Poi H, Carpenter JE, et al. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to ß₃. Circulation 2003; 108:336-341 [49].) Color-coded map of signal enhancement produced by microbubbles that corresponds to A. This map, in which greatest signal enhancement is shown in white and less profound signal enhancement in red, shows regions of prominent microbubble deposition, indicating areas of marked angiogenesis.