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Fig. 5B —Direct imaging of angiogenesis in mouse model of
atherosclerosis using MRI and paramagnetic nanoparticles targeted against
ß3 integrin. (Reprinted with permission
from Winter PM, Morawski AM, Caruthers SD, et al. Molecular imaging of
angiogenesis in early-stage atherosclerosis with
ß3-integrin-targeted nanoparticles.
Circulation 2003; 108:2270-2274
[51].) Axial image using same
technique and at same location as A after administration of
paramagnetic nanoparticles and after subjecting image to semiautomated
segmentation shows enhancement of regions of angiogenesis in aortic wall.