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Fig. 6 —Direct imaging of angiogenesis in rabbit tumor model using MRI and paramagnetic nanoparticles targeted against ß₃ integrin. Color-coded contrast-enhanced T1-weighted image of carcinoma implanted in rabbit shows areas of contrast enhancement coded by yellow pixels, which represent deposition of nanoparticles in regions of angiogenesis. Note that distribution is preferentially in tumor periphery. (Reprinted with permission from Winter PM, Caruthers SD, Kassner A, et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel ß₃-targeted nanoparticle and 1.5 Tesla magnetic resonance imaging. Cancer Res 2003; 63:5838-5843 [52].)