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Fig. 1B —62-year-old man with glioblastoma multiforme. Depiction of changes in leakage of contrast material (a reflection of degree of permeability across blood-brain barrier) after administration of antiangiogenic agent directed against vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Series of images shows additional physiologic information provided by dynamic imaging relative to solely anatomic information provided by conventional MRI. Because imaging findings solely reflect effect of angiogenesis (i.e., permeability), this technique is an example of indirect imaging of angiogenesis. Color-coded map derived from dynamic contrast-enhanced imaging sequence before therapy (corresponding to A) shows degrees of contrast enhancement (changes in signal intensity) normalized against signal intensity in normal tissue. Color-coded map indicates relative degrees of permeability in each pixel, with blue pixels representing signal intensity that is 120-149% of normal tissue, green pixels representing 140-159% of normal tissue, and red pixels representing > 160% of normal tissue. Note that most pixels are in > 160% range, indicating marked leakage of contrast material.