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Fig. 1C —62-year-old man with glioblastoma multiforme. Depiction of changes in leakage of contrast material (a reflection of degree of permeability across blood-brain barrier) after administration of antiangiogenic agent directed against vascular endothelial growth factor (VEGF) receptor tyrosine kinase. Series of images shows additional physiologic information provided by dynamic imaging relative to solely anatomic information provided by conventional MRI. Because imaging findings solely reflect effect of angiogenesis (i.e., permeability), this technique is an example of indirect imaging of angiogenesis. Contrast-enhanced axial T1-weighted image obtained 30 days after initiation of therapy shows mild decrease in size of mass.